1. DRUGS USED IN C.H.F.
Drugs used in C.H.F. are (5 Ds):
1. Digitalis group of drugs e.g. Digitoxin, Digoxin
2. Dopamine & Do scarceamine (sympathomimetics)
3. Diesterase (phosphor-diesterase) inhibitors e.g. Amrinone, Milrinone
4. Dilators of both arterioles and venules (decrease CHF mortality also)
i. ACE inhibitors e.g. Captopril, Enalapril
ii. Dihydrallazine + Isosorbide dinitrate
5. Diuretics kindred loop-the-loop diuretics, thiazides & potassium sparing diuretics
2. DRUGS USED IN ARRHYTHMIAS
I.Drugs for supraventricular arrhythmias:
AAdenosine
BBeta-blockers e.g. Propanolol
CCalcium channel blockers e.g. Verapamil
DDigoxin
II.Drugs for ventricular arrhythmias:
Lignocaine and Mexiletine.
LIGNOCAINE is the main drug used. Its features are:
L locally administered as local anaesthetic.
I Inactive orally so…
G Given I.V. for anti-arrhythmic action, which is due to…
N Na+ channel finish which occur in…
O Only inactive dry land of Na+ channels.
C CNS side effects like convulsions occur on high doses.
A Action lasts simply 15 minutes due to rapid redistribution.
I Inhibits Purkinje fibers and ventricles but…
N No effect on AVN & SAN, so…
E Effective in ventricular arrhythmias only (Not supraventricular).
urgency uses like to prevent arrhythmias following Ac.
M.I.. cardiac surgery and digitalin toxicity.
III.Drugs for both supraventricular and ventricular arrhythmias:
Quinidine, Procainamide, Disopyramide, Propafenone and Amiodarone.
AMIODARONE is the drug with prominent actions.
A Antiarrhythmic.
M Multiple actions i.e. block k+, Na+, Ca++ channel & beta receptors.
I Iodine containing (so numerous interfere with thyroid functions).
O Orally used mainly.
D Duration of action is very long (t1/2 3-8 weeks ).
A APD & ERP increases (so conduction decreases & depress ectopics).
R unsusceptible AF, VT &...If you want to get a full essay, severalize it on our website: Orderessay
If you want to get a full essay, wisit our page: write my essay .
No comments:
Post a Comment